Bioactivity:

SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor�(IC50:1.2 nM;�Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells.�SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic tar

CAS nr:

1523406-39-4

Purity:

98%

Molecular Weight:

443,85

SMILES:

O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31

Formula:

C19H21ClF3N5O2

Pathway:

PI3K/Akt/mTOR signaling,Autophagy

Target:

PI3K,Autophagy