Bioactivity:

VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytosta

CAS nr:

1684386-71-7

Purity:

98%

Molecular Weight:

552,96

SMILES:

O=C(C1=CC=C(O)C=C1O)N(CC2=CC=C(CNC(C(F)F)=O)C=C2)C(C=C3)=CC=C3C4=NC(Cl)=NC=C4C

Formula:

C28H23ClF2N4O4

Pathway:

Metabolism,PI3K/Akt/mTOR signaling

Target:

Dehydrogenase,PDK