Bioactivity:

TD-428 is a highly specific degrader of BRD4(DC50_of_0.32_nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.

CAS nr:

T13105

Purity:

98%

Molecular Weight:

879,38

SMILES:

O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5

Formula:

C43H43ClN10O7S

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain