Bioactivity:

EGFR-IN-5 is a EGFR inhibitor, EGFR-IN-5 with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

CAS nr:

2225887-26-1

Purity:

98%

Molecular Weight:

571,69

SMILES:

OCC(CC1)CCN1C2=NC(NC3=CC=C(F)C=C3)=NC(C=N4)=C2C=C4NC5=NC=C(N6CCC(N(C)C)CC6)C=C5

Formula:

C31H38FN9O

Pathway:

JAK/STAT signaling,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

EGFR,EGFR,EGFR