Bioactivity:

Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC.

CAS nr:

1123838-51-6

Purity:

98%

Molecular Weight:

656,17

SMILES:

O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=NC=C(CNCCOC)C=C4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=C(F)C=C5.Cl

Formula:

C31H28ClF2N5O3S2

Pathway:

Tyrosine Kinase/Adaptors

Target:

c-Met/HGFR