Bioactivity:

AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3K_, _, _ and _, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K

CAS nr:

1253573-53-3

Purity:

98%

Molecular Weight:

517,58

SMILES:

C[C@H](c(cc1-c2nc(N)nc(C)n2)cnc1Nc(cc1F)cnc1OC)N(CC1)CCN1S(C)(=O)=O

Formula:

C22H28FN9O3S

Pathway:

PI3K/Akt/mTOR signaling

Target:

PI3K