Bioactivity:

Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).

CAS nr:

T10583

Purity:

98%

Molecular Weight:

538,5

SMILES:

CN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC

Formula:

C26H21D8Cl2N5O3

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

Bcr-Abl,Bcr-Abl,Bcr-Abl,Src,Src