Bioactivity:

AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

CAS nr:

2196204-23-4

Purity:

98%

Molecular Weight:

385,5

SMILES:

C1CC(CCC1NC2=NC=NC3=C2C(=CN3)C4CCOCC4)N5CCOCC5

Formula:

C21H31N5O2

Pathway:

Cell Cycle/Checkpoint,Immunology/Inflammation,NF-_b,Cell Cycle/Checkpoint

Target:

Haspin Kinase,IRAK,IRAK,CDK