Bioactivity:

Epertinib hydrochloride shows potent antitumor activity.�Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.

CAS nr:

2071195-74-7

Purity:

98%

Molecular Weight:

596,48

SMILES:

CC#C/C(=N\OC[C@H]1COCCN1)/C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl

Formula:

C30H28Cl2FN5O3

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling,JAK/STAT signaling

Target:

HER,HER,EGFR,EGFR,EGFR,HER