Bioactivity:

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

CAS nr:

878739-06-1

Purity:

98%

Molecular Weight:

451,52

SMILES:

CN1C=NC2=C(C=C(NC3=CC(NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)=CC=C3C)C=C2)C1=O

Formula:

C27H25N5O2

Pathway:

MAPK,Apoptosis

Target:

Raf,Apoptosis