Bioactivity:

Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.

CAS nr:

1056636-07-7

Purity:

98%

Molecular Weight:

510,57

SMILES:

O=C(C1=CC=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)C=C1)NCC#N.O=S(O)(C)=O

Formula:

C24H26N6O5S

Pathway:

Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells

Target:

JAK,JAK,JAK,JAK