Bioactivity:

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 _M), DNAPK (IC50, 2.8 _M), PI3K_ (IC50, 3.8 _M), PI3K_ (IC50, 10.3 _M), PI3K_ (IC50, 3 _M) and P

CAS nr:

2135639-94-8

Purity:

98%

Molecular Weight:

492,61

SMILES:

C[C@@H](C1CCOCC1)NC2=C(C(NC)=O)N=NC3=CC=C(C4=CC=C(OCCCN(C)C)N=C4)C=C32

Formula:

C27H36N6O3

Pathway:

DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling

Target:

ATM/ATR,ATM/ATR