Bioactivity:

Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis

CAS nr:

215604-75-4

Purity:

98%

Molecular Weight:

895,99

SMILES:

O=C1C2=C([C@@](OC([C@@](C(C)C)([H])NC([C@@](CC3=CNC=N3)([H])NC(NC4=CC=C(O[C@H]5O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]5O)C=C4)=S)=O)=O)(CC)C(OC2)=O)C=C6C7=NC8=CC=CC=C8C=C7CN61

Formula:

C45H49N7O11S

Pathway:

Target: