Bioactivity:

TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-_ induced growth inhibition in human outer root sheath cells and elongates the anagen phase i

CAS nr:

864374-00-5

Purity:

98%

Molecular Weight:

298,38

SMILES:

CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)NC=N2)=N1

Formula:

C14H10N4S2

Pathway:

Stem Cells

Target:

TGF-beta/Smad