Bioactivity:

Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion).

CAS nr:

2097132-94-8

Purity:

98%

Molecular Weight:

533,6

SMILES:

COC1(CCC(CC1)C1=NC(C)=CC(NC2=NNC(C)=C2)=N1)C(=O)N[C@@H](C)C1=CN=C(C=C1)N1C=C(F)C=N1

Formula:

C27H30FN9O2

Pathway:

Tyrosine Kinase/Adaptors,Apoptosis

Target:

c-RET,c-RET