Bioactivity:

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFR_, and EGFR (IC50s = 0.15, 1.76, and 5.47 ﾵM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 ﾵM)

CAS nr:

179343-17-0

Purity:

98%

Molecular Weight:

405,28

SMILES:

CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl

Formula:

C18H18Cl2N6O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

PDGFR,PDGFR,Src,Src,FGFR,FGFR,EGFR,EGFR,EGFR