Bioactivity:

PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).

CAS nr:

T24623

Purity:

98%

Molecular Weight:

449,91

SMILES:

O=C(NC(C1=NN(C)N=C1)C)C2=CC(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C(OC)C=C2

Formula:

C19H20ClN5O4S

Pathway:

Target: