Bioactivity:

5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1]. [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.

CAS nr:

1453-97-0

Purity:

98%

Molecular Weight:

280,371

SMILES:

CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)cc12

Formula:

C18H20N2O

Pathway:

GPCR/G Protein,Neuroscience,GPCR/G Protein,Neuroscience

Target:

5-HT Receptor,5-HT Receptor,Dopamine Receptor,Dopamine Receptor