Bioactivity:

PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

CAS nr:

T4696

Purity:

98%

Molecular Weight:

455,97

SMILES:

Cl.COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O

Formula:

C25H30ClN3O3

Pathway:

Apoptosis,Immunology/Inflammation,Cell Cycle/Checkpoint

Target:

PD-1/PD-L1,PD-1/PD-L1,PD-1/PD-L1