Bioactivity:

Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochro

CAS nr:

37905-08-1

Purity:

98%

Molecular Weight:

330,42

SMILES:

CC1=C2[C@H]3O[C@]33CC[C@@H]4C(C)(C)CCC[C@@]4(C)C3[C@H]3O[C@@]23OC1=O

Formula:

C20H26O4

Pathway:

Immunology/Inflammation,Apoptosis,Proteases/Proteasome,Apoptosis,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,Chromatin/Epigenetic,MAPK,Stem Cells,JAK/STAT signaling,Stem Cells,Angiogenesis,JAK/STAT signaling,Apoptosis,Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,NF-_b,MAPK,MAPK

Target:

IL Receptor,TNF,Caspase,Caspase,mTOR,PI3K,JAK,JNK,STAT,STAT,JAK,JAK,JAK,BCL,Akt,Akt,NF-_B,p38 MAPK,ERK