Bioactivity:

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 _M), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.

CAS nr:

170713-71-0

Purity:

98%

Molecular Weight:

228,295

SMILES:

CC(C)c1ncc(Cc2ccccc2)[nH]c1=O

Formula:

C14H16N2O

Pathway:

Microbiology/Virology,Proteases/Proteasome

Target:

Antibacterial,Cysteine Protease