Bioactivity:

PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels�in vivo/vitro�by directly inhibiting autotaxin; reduces LPA levels

CAS nr:

1144035-53-9

Purity:

98%

Molecular Weight:

478,33

SMILES:

C1CN(CCN1CCC(=O)c1cc2c(cc1)[nH]c(=O)o2)C(=O)OCc1cc(cc(c1)Cl)Cl

Formula:

C22H21Cl2N3O5

Pathway:

Metabolism

Target:

PDE