Bioactivity:

SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and caspase-3.

CAS nr:

1255099-06-9

Purity:

98%

Molecular Weight:

405,91

SMILES:

O=C(NCC1=CC=CC=C1)CSC2=NC3=CC=C(NC(CCl)=O)C=C3S2

Formula:

C18H16ClN3O2S2

Pathway:

Proteases/Proteasome,Apoptosis,MAPK,MAPK,Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,Cell Cycle/Checkpoint

Target:

Caspase,Caspase,JNK,MAPK,Akt,Akt,Rho