Bioactivity:

JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 15 nM for EGFRL858R/T790M.

CAS nr:

T11713

Purity:

98%

Molecular Weight:

464,54

SMILES:

O=C(NC1=NC=CS1)C(N2C(C(C=C(C3=CC(C=CN4)=C4C=C3)C=C5)=C5C2)=O)C6=CC=CC=C6

Formula:

C27H20N4O2S

Pathway:

Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic

Target:

JAK,JAK,JAK,JAK