Bioactivity:

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.�EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, i

CAS nr:

1808714-73-9

Purity:

98%

Molecular Weight:

368,34

SMILES:

C=CC(Nc(cc(cc1)NC(c2cn(-c(cccc3)c3F)nc2)=O)c1F)=O

Formula:

C19H14F2N4O2

Pathway:

Membrane transporter/Ion channel,Others,Autophagy

Target:

Proton pump,Others,Autophagy