Bioactivity:

eIF4A3-IN-1 �is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 _M;�Kd=0.043 _M), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 _M and can

CAS nr:

2095486-67-0

Purity:

98%

Molecular Weight:

588,88

SMILES:

ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2

Formula:

C29H23BrClN5O2

Pathway:

Others

Target:

Others