Bioactivity:

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.

CAS nr:

927880-90-8

Purity:

98%

Molecular Weight:

518,41

SMILES:

CN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC2=C1C=CC(OC1=CC=NC(=C1)C1=NC=C(N1)C(F)(F)F)=C2

Formula:

C24H16F6N6O

Pathway:

MAPK,Tyrosine Kinase/Adaptors,Angiogenesis,Autophagy,Apoptosis

Target:

Raf,VEGFR,VEGFR,Autophagy,Apoptosis