Bioactivity:

SEL120-34A monohydrochloride is an ATP-competitive and selective inhibitor of CDK8(CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8),has anti-tumor activity.

CAS nr:

T10744L2

Purity:

98%

Molecular Weight:

450,6

SMILES:

CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl

Formula:

C15H19Br2ClN4

Pathway:

Cell Cycle/Checkpoint

Target:

CDK