Bioactivity:

SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM).

CAS nr:

135897-06-2

Purity:

98%

Molecular Weight:

393,39

SMILES:

O=C1NC(C(C2=C3N(C4CCC5O4)C6=CC=CC=C62)=C1C7=C3N5C8=CC=CC=C78)=O

Formula:

C24H15N3O3

Pathway:

Cytoskeletal Signaling,Chromatin/Epigenetic,Cell Cycle/Checkpoint

Target:

PKC,PKC,Chk