Navtemadlin TQ0127
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Specifications
| 1mg/5mg/10mg/25mg/50mg/100mg |
Bioactivity:
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
CAS nr:
1352066-68-2
Purity:
98%
Molecular Weight:
568,55
SMILES:
CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O
Formula:
C28H35Cl2NO5S
Pathway:
Apoptosis,Ubiquitination
Target:
Mdm2,E1/E2/E3 Enzyme