Bioactivity:

Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2.

CAS nr:

802539-81-7

Purity:

98%

Molecular Weight:

460,57

SMILES:

CNC(=O)C1=NN(C)C2=C1C(C)(C)CC1=CN=C(NC3=CC=C(C=C3)N3CCN(C)CC3)N=C21

Formula:

C25H32N8O

Pathway:

Tyrosine Kinase/Adaptors,Autophagy,Cell Cycle/Checkpoint

Target:

Trk receptor,Autophagy,CDK