Bioactivity:

NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD protei

CAS nr:

1884640-99-6

Purity:

98%

Molecular Weight:

353,4

SMILES:

O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O

Formula:

C18H15N3O3S

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain