Bioactivity:

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1

CAS nr:

2374740-21-1

Purity:

98%

Molecular Weight:

526,36

SMILES:

CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O

Formula:

C23H23Cl2F2N5O3

Pathway:

Cytoskeletal Signaling,PI3K/Akt/mTOR signaling

Target:

Akt,Akt