Bioactivity:

GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.

CAS nr:

942918-07-2

Purity:

98%

Molecular Weight:

507,63

SMILES:

CCN1C=C(C(=N1)C1=CC=C(NC(=O)N(C)C)C=C1)C1=C2C=C(NC2=NC=C1)C1=CC=CC(CN(C)C)=C1

Formula:

C30H33N7O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,PI3K/Akt/mTOR signaling,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Apoptosis

Target:

FLT,FLT,Tie-2,AMPK,Aurora Kinase,Aurora Kinase,Apoptosis