Bioactivity:

PYZD-4409 causes cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells. PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 (IC50: 20 _M (cell-free enzymatic assay)).

CAS nr:

423148-78-1

Purity:

98%

Molecular Weight:

351,67

SMILES:

FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl

Formula:

C14H7ClFN3O5

Pathway:

Others,Ubiquitination

Target:

Others,E1/E2/E3 Enzyme