Bioactivity:

_-Stat (NSC37044) is a specific and atypical PKC-_ inhibitor, with an IC50 of 5 _M. _-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. _-Stat (0.1-20 _M) shows only 13% inhibition on PKC-_ at 20 _M, but shows a significant inhibition on PKC-_ as 51% at 5 _M level[1]._-Stat (0.1-10 _M; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1]._-Stat (7 or 10 _M; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2]._-Stat (5 _M; 3 d) shows a significant diminution of phosphorylated, total PKC-_, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1]._-Stat (5 _M; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. [1]. Ratnayake WS, et, al. Oncogenic PKC-_ activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-_ and PKC-_ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463.[2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.

CAS nr:

3316/2/7

Purity:

98%

Molecular Weight:

384,36

SMILES:

N/A

Formula:

C10H8O10S3

Pathway:

Target: