Bioactivity:

ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK). Acalabrutinib is an irreversible and highly selective BTK inhibitor (IC50: 3 nM; EC50: 8 nM).

CAS nr:

2230757-47-6

Purity:

98%

Molecular Weight:

481,51

SMILES:

O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C(C(CCCNC(C#CC)=O)=O)=N3)C=C2

Formula:

C26H23N7O3

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors

Target:

BTK,BTK