Bioactivity:

JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.

CAS nr:

2209085-22-1

Purity:

98%

Molecular Weight:

920,14

SMILES:

O=C(N([C@H]1CC[C@]2(C)C3CC[C@]4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CC[C@@]4([H])[C@]3([H])CCC2C1)C)CCOCCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O

Formula:

C53H69N5O9

Pathway:

Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,EGFR