Bioactivity:

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

CAS nr:

56932-43-5

Purity:

98%

Molecular Weight:

503,42

SMILES:

[Na+].[Na+].Oc1c(cc(c2cccnc12)S([O-])(=O)=O)\N=N\c1ccc2cc(ccc2c1)S([O-])(=O)=O

Formula:

C19H13N3O7S2�2Na

Pathway:

Metabolism,Apoptosis

Target:

Phosphatase,Apoptosis