Bioactivity:

IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

CAS nr:

548779-60-8

Purity:

98%

Molecular Weight:

454,12

SMILES:

C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl

Formula:

C20H12Cl4N2O2

Pathway:

Stem Cells

Target:

Smo