Bioactivity:

AMG-548 is an orally active and selective p38_ inhibitor (Ki=0.5 nM), shows slightly selective over p38_ (Ki=36 nM) and >1000 fold selective against p38_ and p38_ and is also extremely potent in the inhibition of whole blood LPS stimulated TNF_ (IC50=3 nM

CAS nr:

864249-60-5

Purity:

98%

Molecular Weight:

461,56

SMILES:

O=C1N(C)C(NC[C@@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4

Formula:

C29H27N5O

Pathway:

MAPK

Target:

p38 MAPK