Bioactivity:

ML221 is a potent�apelin /APJ�functional antagonist, inhibiting apelin-13-mediated activation of APJ, with�IC50s of 0.70 _M in the cAMP assay, and 1.75 _M in the _-arrestin assay, and�EC80�of 10 nM in both assays.

CAS nr:

877636-42-5

Purity:

98%

Molecular Weight:

385,35

SMILES:

C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

Formula:

C17H11N3O6S

Pathway:

GPCR/G Protein

Target:

Apelin receptor