Bioactivity:

Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspective

CAS nr:

6199-67-3

Purity:

98%

Molecular Weight:

558,7

SMILES:

C(=O)(C)OC(C)(/C=C/C(=O)[C@](C)(O)[C@H]1[C@@H](C[C@]2([C@@H]3CC=C4C(C(=O)[C@H](C[C@H]4[C@@]3(C(=O)C[C@]12C)C)O)(C)C)C)O)C

Formula:

C32H46O8

Pathway:

Metabolism,Stem Cells,JAK/STAT signaling,Cytoskeletal Signaling,Autophagy,Apoptosis,PI3K/Akt/mTOR signaling,Angiogenesis,Chromatin/Epigenetic

Target:

Endogenous Metabolite,STAT,STAT,Integrin,Autophagy,Apoptosis,PTEN,HIF,HIF