Bioactivity:

BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC etc.

CAS nr:

702674-56-4

Purity:

98%

Molecular Weight:

471,35

SMILES:

Brc1cnc(Nc2cc(NC(=O)N3CCCC3)ccc2)nc1NCCc1cnc[nH]1

Formula:

C20H23BrN8O

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,PI3K/Akt/mTOR signaling,Apoptosis,Cell Cycle/Checkpoint,Cell Cycle/Checkpoint

Target:

VEGFR,VEGFR,PKA,PDK,Apoptosis,Chk,CDK