Bioactivity:

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery[1]. [1]. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

CAS nr:

115-20-8

Purity:

98%

Molecular Weight:

149,4

SMILES:

OCC(Cl)(Cl)Cl

Formula:

C2H3Cl3O

Pathway:

Metabolism,Membrane transporter/Ion channel

Target:

Endogenous Metabolite,Potassium Channel