Bioactivity:

Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.

CAS nr:

1234015-54-3

Purity:

98%

Molecular Weight:

438,31

SMILES:

Cl.Cl.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

Formula:

C18H21Cl2N7O2

Pathway:

Cell Cycle/Checkpoint,Apoptosis,PI3K/Akt/mTOR signaling,MAPK

Target:

Chk,Apoptosis,S6 Kinase,S6 Kinase