Bioactivity:

Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 is a Rheb inhibitor (IC50: 2.1_ﾵM in the Rheb-IVK assay). NR1 also is a selective mTORC1 inhibitor.

CAS nr:

2216763-38-9

Purity:

98%

Molecular Weight:

578,3

SMILES:

O=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O

Formula:

C25H19BrCl2N2O3S

Pathway:

Others

Target:

Others