Bioactivity:

Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.

CAS nr:

683808-78-8

Purity:

98%

Molecular Weight:

438,24

SMILES:

O=C(O)CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=CC=CC=C3C(F)(F)F

Formula:

C20H15BrF3NO2

Pathway:

Target: