Bioactivity:

2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2_-deoxy-2_-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1]. 2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 _M in Huh7 cells[1]. [1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

CAS nr:

10212-20-1

Purity:

98%

Molecular Weight:

245,21

SMILES:

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F)c(=O)n1

Formula:

C9H12FN3O4

Pathway:

Cell Cycle/Checkpoint,DNA Damage/DNA Repair,Microbiology/Virology

Target:

Nucleoside Antimetabolite/Analog,Nucleoside Antimetabolite/Analog,Influenza Virus