Bioactivity:

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

CAS nr:

398493-79-3

Purity:

98%

Molecular Weight:

501,62

SMILES:

CCC1=CC=CC(CC)=C1NC(=O)N1CC2=C(C1)C(NC(=O)C1=CC=C(C=C1)N1CCN(C)CC1)=NN2

Formula:

C28H35N7O2

Pathway:

Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint

Target:

PLK,FGFR,FGFR,Aurora Kinase,Aurora Kinase